The Effect Of New Protein Synthesis At Prl Cortex - 900 Words

training. Mice infused with anisomycin (n= 12) immediately after conditioning showed impairment in contextual fear memory compared with vehicle-infused animals (saline, n=18) when tested 24 hours after CFC training (DF=28, F=7.19, t-test: p 0.05) (Figure 2A). Surprisingly, irrespective of the overall decrease in freezing percentage, mice injected with anisomycin did not show any statistical difference in the level of freezing within the first 2 minutes of the test (Figure 2B). By the third minute of testing, ANI-injected mice show a significant decrease in their level of freezing, showing statistical significant differences until the end of the test (drug Ãâ€" memory minutes of test DF=28, F=13.16, t-test p 0.01; DF=28, F=7.66, t-test p 0.01; DF=28, F=5.46, t-test p 0.05) (Figure 2B). These results suggested that new protein synthesis at PrL cortex is critical for the encoding of contextual fear memories. To further understand new protein synthesis at PFC, we asked whether other subregions of PFC are also critical for encoding of contextual fear memories. To address this question, we studied the role of cingulate cortex 1 (CG1) region of PFC in encoding. We injected anisomycin to inhibit protein synthesis at CG1. Four separate groups of animals received anisomycin and saline infusions into the adjacent CG1 (Saline, n= 8; ANI, n=6; Figure 2 C and D). As in the case of Prl cortex, anisomicyn was injected shortly after CFC training. Measurements of freezing at 24 hoursShow MoreRelatedThe Encoding of Contextual Fear Conditioning1296 Words   |  5 PagesThe formation of new memories requires protein synthesis dependent changes in synaptic structure and plasticity in the hippocampus. Studies in humans and animals suggest that these memories are initially stored in hippocampus but later transferred to cortex for permanent storage. This phenomenon is described as systems consolidation of m emories. While the specific role for new protein synthesis in hippocampus in early encoding of memories is established, whether protein synthesis in medial prefrontalRead MoreEssay on The Endocrine System Exam3777 Words   |  16 PagesMatch the hormone to the Gland that Secretes it and the Target organ it effects Hormone ACTH ADH CRH FSH GHRH GnRH hGH (Somatotropin) LH MSH Oxytocin PIH (Dopamine) PRL (Prolactin) Somatostatin (GHIH) TRH TSH A. Liver B. Thyroid C. Gonads – Sperm or Ova D. Gonads - Testosterone E. Mammary Glands - Milk Secreted by 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Target organ 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 F. Adrenal cortex Glucocorticoids G. Brain - Melanin H. Anterior Pituitary I. PosteriorRead MoreEssay on The Endocrine System: Billys Case1294 Words   |  6 Pagesstructure of the pituitary gland and hypothalamus facilitate for hormone secretion. The pituitary gland consists of the posterior and anterior lobe. It is lined with specialised epithelial cells which secrete hormones to be released into the blood to effect target cells. Hormones are regulated, controlled and secreted initially by the hypothalamus. The hypophyseal portal system and infudibulum stem connect the hypothalamus to the pituitary gland to enable the hypothalamus to send hormones to the pituitaryRead MoreSocm Study Guide Essay30404 Words   |  122 PagesPhysiology – study of functions of living cells Special Physiology – study of the physiology of specific organs System Physiology – considers all aspects of the function of specific organ systems Pathological physiology (Pathology) – studies the effects of disease on organ or syst4m functions Identify the major levels of organization in living organisms. A. Chemical B. Cellular level C. Tissue level D. Organ level E. Organ system level F. Organism level Identify the